How Mouth and Gut Bacteria Influence Parkinson’s Cognitive Decline
A new study has found a fascinating connection between changes in gut and mouth bacteria and cognitive decline in individuals with Parkinson’s disease. Researchers have identified harmful microbes and their toxins in the gut of Parkinson’s patients with dementia, suggesting a potential link between oral hygiene, gut health, and neurodegeneration.
Study Details
The study, published in Gut Microbes, analyzed gut and mouth bacteria in 114 individuals, including 41 Parkinson’s patients with mild cognitive impairment and 47 Parkinson’s patients with dementia. Stool and saliva samples were collected and analyzed, revealing significant differences in the microbiome between the two groups.
Research Findings
Researchers discovered a link between the composition and function of gut and oral microbiomes and cognitive impairment and progression in Parkinson’s disease. Through deep sequencing and analysis, they identified shifts in specific microbial genes and metagenomic species that may play a role in cognitive decline.
Implications of the Study
The findings of this study suggest that the migration of bacteria from the mouth to the gut could influence the progression of cognitive decline in Parkinson’s disease. By understanding the role of the microbiome in neurodegeneration, researchers may uncover new strategies for early diagnosis and potential treatment options.
Future Research
Further research is needed to explore the intricate connections between oral-gut-brain axis virulence and Parkinson’s disease pathophysiology. By investigating the impact of specific microbial signatures on cognitive function, scientists aim to develop targeted interventions to slow or halt cognitive decline in individuals with Parkinson’s.
Reference: Clasen F, Yildirim S, Arikan M, et al. Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson’s disease and cognitive decline pathophysiology. Gut Microbes. Published online May 27, 2025. doi: 10.1080/19490976.2025.2506843.
