Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 1% of individuals over the age of 60, highlighting the impact that advancing age has on the risk of developing this condition. In the UK, over 127,000 individuals are affected, while in the USA, the number rises to 500,000. As individuals age, the prevalence of PD increases, with 5% of those over 85 being impacted.

Aging is the biggest risk factor for Parkinson’s disease, suggesting that mechanisms driving the aging process promote PD neurodegeneration. This age-related dysfunction makes neurons vulnerable to environmental and genetic factors that contribute to the development of the disease.

Studies have shown an association between the accumulation of certain proteins and the onset of Parkinson’s disease, highlighting the importance of understanding the link between aging and PD. The exact etiology of PD is still unknown, but research suggests that aging plays a significant role in dopamine neuron vulnerability, leading to motor dysfunction.

As the population continues to age, the health, social, and economic impact of Parkinson’s disease is expected to rise. Age remains the biggest risk factor for developing this condition, emphasizing the importance of further research into the connection between aging and PD.